Dr Dr. Ricardo Lloyd
MD, PhD - University of Wisconsin School of Medicine and Public Health, Madison
Seminar Title: Epithelial Mesenchymal Transition (EMT) and Thyroid Cancer Stem-Like Cells
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Anaplastic thyroid carcinoma (ATC) is one of the most lethal human cancers without a known cure. These cancers may arise by dedifferentiation from papillary thyroid carcinoma (PTC) or arise from embryonic stem cells that become malignant.
Cancer stem-like cells (CSCs) represent a small subset of malignant cells in a cancer that divide asymetrically, are resistant to chemo-irradiation therapy and may be responsible for cancer recurrence and metastasis.
We have developed several models to study thyroid CSCs from PTCs and ATCs and have made clonogenic cell lines of thyroid CSCs. Data on the relationship of EMT to CSCs, the study of CSC clones in vitro and in vivo and the response of these clones to chemotherapeutic agents will be discussed.
Dr. Ricardo Lloyd is a Professor of Pathology (with tenure) at the University of Wisconsin School of Medicine and Public Health. He earned his MD and PhD degrees from the University of Wisconsin in 1975 followed by residency training in anatomic and clinical pathology at the same institution. He did a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center in New York.
Dr. Lloyd joined the faculty at the University of Michigan in 1981 where he rose to Professor of Pathology and was the Warthin-Weller Professor of Pathology. He joined the Mayo Clinic in 1993 where he was the Vernon F. and Earline D. Dale Professor at Mayo Foundation. He moved to the University of Wisconsin School of Medicine and Public Health in 2010 where he is the Director of the Cancer Center Biobank and the Director of the Translational Research in Pathology Laboratory.
Dr. Lloyd’s main area of interest is in endocrine pathology. He documented the aggressive biological behaviour of the tall cell variant of papillary thyroid carcinoma in 1987 with a clinicopathological study published in the American Journal of Surgical Pathology and in 2010 he and his collaborators described a new aggressive variant of papillary thyroid carcinoma, the hobnail variant. Dr Lloyd has published over 490 original manuscripts and written or edited seven books and more than 30 book chapters.
In addition to his work in endocrine pathology, Dr. Lloyd has served as President of the Endocrine Pathology Society and President of the United States and Canadian Academy of Pathology. He is on the editorial board of ten journals and is Editor-in Chief of Human Pathology. He enjoys teaching undergraduate students, medical students, and residents. He is also a mentor to many faculty members.