Dr Praveen Arany
BDS, MDS, MMSc, PhD
Assistant Professor, School of Dental Medicine, University of Buffalo, USA
Seminar Title: Precision Medicine: Molecular Mechanisms Promoting Clinical Translation of Photobiomodulation Therapy
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The role of light in human health has been a key aspect since ancient civilizations from our ability to see (vision), Vitamin D metabolism, and circadian rhythm to psychosocial state. The use of biophotonics devices in healthcare are widely pervasive from simple operative lighting, diagnostic tools to precision surgical lasers. The use of low dose light for therapy to alleviate pain and inflammation and promote healing and regeneration is termed Photobiomodulation (PBM) therapy. It has been around for over six decades but a lack of our understanding of fundamental light-biological tissue interactions has prevented it begin adopted in mainstream medicine. Recent progress in molecular mechanisms mediating PBM responses have enabled more rigorous, precision medicine approaches to effectively translate this fascinating therapy for a wide range of ailments. This talk will address prior work form our group that demonstrated a therapeutic PBM pathway involving direct activation of a growth factor, TGF-β1 and its ability to direct differentiation of stem cells for tissue regeneration. We have also recently demonstrated the use of clinical and molecular biomarkers that is enabling precise dosing thresholds for PBM therapy. The sheer breadth of clinical applications for PBM therapy is poised to change our fundamental approach to clinical medicine with an emphasis on promoting inherent healing and regeneration. Major progress in this field is being driven by our better understanding of its molecular mechanisms leading to clinical regimens accounting for precise anatomical and disease-specific PBM responses
Praveen R Arany DDS, PhD, trained as a dentist and oral pathologist. He completed a joint PhD-Residency program at Harvard University as a Harvard Presidential Scholar. He has certificates in clinical translational research from Harvard Medical School and National Institute of Health (NIH). He pursued postdoctoral fellowships at Indian Institute of Sciences, Bangalore; National Cancer Institute (NCI), Bethesda and Harvard School of Engineering and Applied Sciences, Cambridge. He was an Assistant Clinical Investigator at National Institute of Dental and Craniofacial Research, NIH, Bethesda and currently is an Assistant Professor, Oral Biology, School of Dental Medicine, University at Buffalo, New York.
He has over 45 publications and 4 book chapters; recipient of numerous awards such as NCI Director's Young Investigator Award, Wound Healing Society's Young Investigator Award, Eugene Seidner scholar, Horrace Furomoto Young Investigator award. He has been invited to speak in various national and international forums, reviews for over 25 scientific journals and several grant agencies and serves on 9 journal editorial boards. Dr. Arany holds several leadership positions - current President (2014-2016) of North American Association for Photobiomodulation Therapy (NAALT), Chair of Lasers in Dentistry track, Americal Society of Lasers in Surgery and Medicine (ASLMS) and Co-Chair of the International Society of Optics and Photonics (SPIE) conference on Mechanisms of Photobiomodulation therapy.
Dr. Arany’s research is focused on the molecular mechanisms and clinical translation of light therapy to promote wound healing and tissue regeneration.