Principal speaker
Dr Hannah Strobel
Menzies Health Institute Queensland Program Seminar Series
Infectious Diseases & Immunology - Host Professor Nigel McMillan
Dr Hannah Strobel - Title: Fabricating Vascularized Tissues
Abstract -
There is an enormous need for engineered tissues, both as replacements for diseased and damaged organs, and as tools for disease modelling and drug screening. Every tissue is unique, requiring different materials, fabrication procedures, and maturation conditions. However, all of these tissues require a vascular supply to maintain cellular health and support tissue maturation. Existing methods for perfusing tissues are often ineffective, perfusing only parts of the tissue and leaving zones of necrosis. At Advanced Solutions, we have developed a technology for isolating whole intact microvessels from adipose tissue. When embedded in a matrix, microvessels, sprout, grow, and form an interconnected vascular network comparable to the native vasculature. We have applied this technology to a variety of different systems, proving the utility of our microvessel system for tissue vascularization, and improving outcomes in vivo and in vitro.
Biography -
Hannah Strobel Ph.D. is a Fellow at Advanced Solutions Life Sciences (ASLS) in Manchester, New Hampshire. Her focus at ASLS is on tissue vascularization, from understanding mechanisms that guide neovessel growth, to building functional vascularized tissues and automating tissue biomanufacturing. Prior to joining ASLS, Hannah received her B.S. from Rensselaer Polytechnic Institute in Troy, New York, and Ph.D. in Biomedical Engineering from Worcester Polytechnic Institute (WPI) in Worcester, Massachusetts. The focus of her doctorate was on fabricating tissue engineered blood vessels for drug screening, which led to numerous published papers and a patent pending, and an award for outstanding graduate student. She also spent a semester doing biomaterials research in an international laboratory at the National University of Ireland in Galway. She is excited to be a part of this progressive, interdisciplinary field as we push tissue engineering from the benchtop to the clinic.
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