Mini Symposia: Big Data including Genomics

Mini Symposia:  Big Data including Genomics
Mini Symposia: Big Data including Genomics

Principal speaker

Liz Ryan

Other speakers

Nick Matigian; Oak Hatzimanolis; Hanna Sidjabat; Gareth Price


The stats-in-action mini-symposia on methods involving statistics are designed to showcase the variety of ways in which Griffith researchers and friends have put statistics to good use, in practice, to support an evidence-based approach to research.

Analytics and "big data" are rapidly growing sources of data for research and have become increasingly important for biomedical research, in the form of "omics data. This online mini-symposium will bring together researchers from across Griffith University and south-east Queensland to explore exciting applications of big data (including 'omics') technologies, where these will later be used as input into bioinformatics and statistical methods (see symposium on bioinformatics). This mini-symposium is hosted by the Research and Education Development team, Griffith University and QCIF Facility for Advanced Bioinformatics (QFAB). Topics include;

Data integration (e.g. "omics integration), pre-processing of data

Visualisation methods for high throughput data

Software/platforms to assist in analysing and sharing/hosting big data, e.g., mixOmics, Galaxy Australia for 'omics.

Agenda

11.30 am - Welcome

11.30 am - Using Public Big Data, It's Free!
Presenter: Nicko Matigian
Generating big data is expensive, in terms of time, money and computational storage. We investigate how publicly available big data can be used to complement and/or generate hypotheses.

12.10 pm - Investigating algorithms to process and identify circular RNA data and obtain gene counts for patients with Schizophrenia
Presenter: Oak Hatzimanolis
There is a lack of understanding about circular RNAs and their role in regulation of cellular mechanisms. This is very apparent for Schizophrenia, as there is a severe lack of research into this type of non-coding RNA implicated in schizophrenia. We hypothesize that we can identify circular RNAs present in the RNA sequencing data derived from olfactory neuronal stem cells produced from patient and control samples and that there will be differential expression for this type of RNA

12.30 pm - Using SWATH mass spectrometry and principal component analysis to understand bacterial proteome changes of potential probiotics in the pressure of pathogens.
Presenter: Hanna Sidjabat
In the era of the continuous increase of antibiotic resistance, an alternative to antibiotic treatment, such as through the use of probiotics should be further investigated. Here, we developed a possible technique to analyse the bacterial proteomic changes of potential probiotics in the pressure of pathogens. We previously tested the proteomic changes of pathogens under the pressure of antibiotics at sub-minimum inhibition concentration using sequential window acquisition of all theoretical mass spectra (SWATH).

1.00 pm - Galaxy Australia - enabling open and reproducible analysis on Australian national computers
Presenter: Gareth Price
Galaxy Australia is online platform for biological research that enables access to national cloud and HPC computer resources for processing your data, supported by reference datasets and a collection of over 1,000 analytical tools, all without the need for programming experience. The platform is accessed through any web enabled device, allows easy sharing of data with your collaborators, has a complete audit trail with citations allowing for seamlessly Galaxy Australia to publication transition.
This presentation will focus on the distributed resources that allows for a diverse range of analyses, with examples shown. Recently added features for import and export of data from your 1Tb AARNet Cloudstor allocation will be showcased as will the ability to create single click button complex analytical workflows. Galaxy Australia is supported by a rich collection of training materials and an active community of scientists, nationally and globally.

1.40 pm - Discussion

2.00 pm - Close

Please follow the below link for a full breakdown of each discussion.
Book of Abstracts - Omics and big data

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RSVP on or before Friday 30 October 2020 15.22 pm, by email RED@griffith.edu.au , or by phone 0755529107 , or via https://events.griffith.edu.au/d/l7qfnk/4W

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